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Updated: Jun 26, 2026

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

A sensitive ultrasonic imaging method for targeted contrast microbubble detection.

Hairong Zheng¹, Dustin E Kruse, Douglas N Stephens

¹Department of Biomedical Engineering, University of California at Davis, CA 95616, USA. hr.zheng@siat.ac.cn

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|January 24, 2009

Summary

This summary is machine-generated.

This study introduces a new ultrasound molecular imaging technique using wideband transient high frequency acoustic emission. The method achieves significant tissue signal suppression and enhanced targeted bubble contrast for improved imaging sensitivity.

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Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

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Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound

Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound

Published on: March 4, 2015

Area of Science:

Medical Imaging
Biomedical Engineering
Acoustics

Background:

Ultrasound molecular imaging requires selective and sensitive techniques.
Ultrasound contrast agents can emit acoustic signals for imaging.
Targeted imaging aims to visualize specific biological markers.

Purpose of the Study:

To develop and evaluate a novel targeted imaging technique for ultrasound molecular imaging.
To enhance sensitivity and selectivity in ultrasound molecular imaging.
To improve the contrast-to-free bubble signal ratio.

Main Methods:

Utilized wideband transient high frequency acoustic emission from ultrasound contrast agents.
Employed a novel multi-frequency co-linear array transducer (1.4 MHz outer, 5.3 MHz center).
Implemented a composite imaging sequence involving transmit-at-low-frequency-receive-at-high-frequency (TLRH) and radiation force pulse for bubble adhesion, followed by signal subtraction.

Main Results:

Achieved up to 33 dB suppression of tissue signals.
Obtained a targeted bubble contrast-to-free bubble signal ratio of up to 23 dB.
Demonstrated successful targeted imaging in a phantom with biotin microbubbles and avidin-coated cellulose.

Conclusions:

The developed targeted imaging technique offers selective and sensitive ultrasound molecular imaging.
The novel multi-frequency array and composite sequence effectively suppress background signals.
This technique shows significant potential for advancing molecular imaging applications.