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Updated: Jun 26, 2026

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons

Published on: August 23, 2016

Interferon gamma in successful pregnancies.

Shawn P Murphy¹, Chandrakant Tayade, Ali A Ashkar

¹Department of Obstetrics and Gynecology, University of Rochester, Rochester, NY, USA.

Biology of Reproduction

|January 24, 2009

Summary

Interferon gamma (IFNG) is vital for a healthy pregnancy, promoting blood vessel growth and placental development. Disruptions in IFNG signaling are linked to pregnancy complications like preeclampsia.

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Area of Science:

Reproductive immunology
Maternal-fetal interface biology

Background:

Interferon gamma (IFNG) is a proinflammatory cytokine crucial during early pregnancy.
It's produced by uterine natural killer cells and trophoblasts, influencing placental development.
Dysregulation of IFNG is implicated in gestational complications such as fetal loss and preeclampsia.

Purpose of the Study:

To review the dynamic roles of Interferon gamma (IFNG) in successful pregnancy.
To summarize IFNG's involvement in various gestational pathologies.

Main Methods:

Literature review of studies on IFNG in pregnancy.
Analysis of IFNG's functions in animal models and human pregnancy.
Examination of IFNG's role in immune responses and trophoblast biology.

Main Results:

IFNG initiates endometrial vasculature remodeling and angiogenesis.
It maintains the decidual component of the placenta.
Trophoblast cells exhibit dampened IFNG responses, aiding fetal survival by resisting Major Histocompatibility Complex (MHC) class II expression.

Conclusions:

Interferon gamma (IFNG) is essential for successful pregnancy outcomes.
Altered IFNG signaling contributes to pregnancy complications.
Trophoblast resistance to IFNG is key for immune tolerance of the semiallogeneic fetus.