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Published on: August 2, 2024
Influence of HyCoSy on spontaneous pregnancy: a randomized controlled trial
L Lindborg1, J Thorburn, C Bergh
1Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, 41345 Göteborg, Sweden. lena.lindborg@vgregion.se
Background:
The aim of the study was to test whether the use of sonography contrast could enhance the chance of spontaneous clinical pregnancy in women undergoing subfertility investigation.
Methods:
Couples with at least 1 year of infertility who were scheduled for a consultation including a hysterosalpingo contrast sonography (HyCoSy) were invited to participate in the study. We compared flushing with water-soluble contrast medium (WSCM) versus no flushing. Randomization sequence was computer generated, stratified for age and group allocation was concealed. Primary outcome was clinical pregnancy defined as a sonographically visible fetal sac, detected within 6 months from randomization. Secondary outcomes were spontaneous miscarriage and birth. Exclusion criteria were female age >or=40 years, severe male infertility, previously known severe tubal infertility and suspected anovulation.
Results:
The mean age of the study population (n = 334) was 31.9 years. Duration of infertility was 2.1 years. The clinical pregnancy rate was 29.2% in the HyCoSy group and 26.5% in the non-flushing group, the difference being 2.7% (95% confidence interval -6.9 to 12.3%, P = 0.63).
Conclusion:
The clinical impression of an enhanced pregnancy rate after performing HyCoSy could not be confirmed. Tubal investigation with sonography using water-soluble contrast has a function as a diagnostic procedure but not in terms of increasing pregnancy rates in subfertile patients.
Trial Registration Number:
ISRCTN20715945.
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