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ST-segment depression as a risk factor in hypertrophic cardiomyopathy

Majid Haghjoo1, Shabnam Mohammadzadeh, Mehdi Taherpour

  • 1Department of Pacemaker and Electrophysiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Mellat Park, Vali-e-Asr Avenue, PO Box 15745-1341, Tehran 1996911151, Iran. majid.haghjoo@gmail.com

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
|January 24, 2009
PubMed

Insights

Electrocardiogram (ECG) ST-segment depression in high lateral leads is a significant predictor of adverse events in hypertrophic cardiomyopathy (HCM) patients. This finding aids in risk stratification for sudden cardiac death or implantable cardioverter-defibrillator therapy.

Area of Science:

  • Cardiology
  • Medical Diagnostics

Background:

  • Hypertrophic cardiomyopathy (HCM) poses a risk for sudden cardiac death.
  • Current electrocardiogram (ECG) criteria lack robust prognostic value for HCM risk stratification.

Purpose of the Study:

  • To investigate the relationship between resting ECG findings and prognosis in patients diagnosed with HCM.
  • To identify specific ECG markers for improved risk stratification in HCM.

Main Methods:

  • Retrospective analysis of 173 HCM patients' data.
  • Assessment of 12-lead ECGs for various parameters including ST-segment deviation and T-wave inversion.
  • Follow-up for a mean of 50 months to record combined endpoints of sudden death or appropriate ICD therapy.

Main Results:

  • ST-segment depression in high lateral leads was significantly associated with increased risk of sudden death or ICD therapy.
  • Syncope and maximal left ventricular wall thickness >= 30 mm were also linked to adverse outcomes.
  • Other ECG findings like LV hypertrophy and LAE did not show prognostic significance.

Conclusions:

  • ST-segment depression in high lateral leads is a novel, significant prognostic marker in HCM.
  • These ECG findings, alongside syncope, can enhance risk stratification for HCM patients.
  • Further research may integrate these ECG markers into clinical guidelines for HCM management.
Abstract

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