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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
Published on: August 8, 2022
ST-segment depression as a risk factor in hypertrophic cardiomyopathy
Majid Haghjoo1, Shabnam Mohammadzadeh, Mehdi Taherpour
1Department of Pacemaker and Electrophysiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Mellat Park, Vali-e-Asr Avenue, PO Box 15745-1341, Tehran 1996911151, Iran. majid.haghjoo@gmail.com
Summary
Electrocardiogram (ECG) ST-segment depression in high lateral leads is a significant predictor of adverse events in hypertrophic cardiomyopathy (HCM) patients. This finding aids in risk stratification for sudden cardiac death or implantable cardioverter-defibrillator therapy.
Area of Science:
- Cardiology
- Medical Diagnostics
Background:
- Hypertrophic cardiomyopathy (HCM) poses a risk for sudden cardiac death.
- Current electrocardiogram (ECG) criteria lack robust prognostic value for HCM risk stratification.
Purpose of the Study:
- To investigate the relationship between resting ECG findings and prognosis in patients diagnosed with HCM.
- To identify specific ECG markers for improved risk stratification in HCM.
Main Methods:
- Retrospective analysis of 173 HCM patients' data.
- Assessment of 12-lead ECGs for various parameters including ST-segment deviation and T-wave inversion.
- Follow-up for a mean of 50 months to record combined endpoints of sudden death or appropriate ICD therapy.
Main Results:
- ST-segment depression in high lateral leads was significantly associated with increased risk of sudden death or ICD therapy.
- Syncope and maximal left ventricular wall thickness >= 30 mm were also linked to adverse outcomes.
- Other ECG findings like LV hypertrophy and LAE did not show prognostic significance.
Conclusions:
- ST-segment depression in high lateral leads is a novel, significant prognostic marker in HCM.
- These ECG findings, alongside syncope, can enhance risk stratification for HCM patients.
- Further research may integrate these ECG markers into clinical guidelines for HCM management.
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