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[Laboratory study of patients with endemic nephropathy]
Glas. Srpska Akademija Nauka I Umetnosti. Odeljenje Medicinskih Nauka
|January 1, 1991
Summary
High-risk pregnancies, including diabetes mellitus and EPH gestoses, show altered immunoglobulin levels. Pregnant diabetics had increased IgG in urine and IgA, while IgM increased in their sera.
Area of Science:
- Immunochemistry
- Obstetrics
- Maternal-Fetal Medicine
Context:
- High-risk pregnancies present unique challenges in maternal and fetal health.
- Diabetes mellitus and EPH gestoses are significant contributors to pregnancy complications.
- Understanding immune system alterations in these conditions is crucial for risk assessment.
Purpose:
- To quantify immunoglobulin G (IgG), M (IgM), and A (IgA) concentrations in maternal serum, cord blood, amniotic fluid, and urine.
- To compare immunoglobulin levels between pregnant women with diabetes mellitus, EPH gestoses, and a control group.
- To identify significant differences in immunoglobulin passage across these high-risk pregnancy cohorts.
Summary:
- Immunoglobulin levels were measured using nephelometry in 60 women across three groups (control, diabetes, EPH gestoses).
- Pregnant diabetics exhibited significantly increased urinary IgG and serum IgM.
- Both high-risk groups showed elevated IgA in cord blood, with decreased IgA in amniotic fluid for the EPH gestoses group.
Impact:
- Findings suggest distinct immunoglobulin profiles associated with diabetes mellitus and EPH gestoses during pregnancy.
- These variations may serve as biomarkers for monitoring high-risk pregnancies.
- Further research is warranted to explore these immunological changes in other high-risk obstetric conditions.