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Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...

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Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

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Ziprasidone-induced spontaneous orgasm.

K Boora, K Chiappone, S Dubovsky

Journal of Psychopharmacology (Oxford, England)

|January 24, 2009

Summary

Antipsychotic medications can cause sexual side effects. This case study reports spontaneous orgasms in a bipolar patient treated with ziprasidone, potentially linked to its 5-HT2 receptor antagonism.

Area of Science:

Neuroscience
Pharmacology
Psychiatry

Background:

Neuroleptic medications are associated with sexual dysfunction in schizophrenic patients.
Rare cases of spontaneous ejaculation during antipsychotic treatment have been documented with specific drugs.

Observation:

A bipolar patient experienced recurrent spontaneous sexual arousal and orgasm.
These events were unprecedented for the patient and occurred during ziprasidone treatment.

Findings:

Ziprasidone may induce spontaneous orgasm, a rare sexual side effect.
This effect could be mediated by 5-HT2 receptor antagonism, facilitating cortical dopamine release.

Implications:

Highlights a potential, rare sexual side effect of ziprasidone.

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Suggests a mechanism involving serotonin and dopamine pathways for drug-induced sexual events.

Warrants consideration of sexual side effects in patients treated with ziprasidone.