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Updated: Jun 26, 2026

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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Depression during pregnancy: rates, risks and consequences--Motherisk Update 2008
1Child and Adolescent Psychiatry, Perinatal Mood Disorders Program, University of Michigan, Ann Arbor, Michigan, USA.
Summary
Postpartum depression affects many women, with screening tools identifying at-risk individuals. However, low treatment-seeking rates persist, highlighting a critical gap in maternal mental healthcare.
Area of Science:
- Obstetrics and Gynecology
- Psychiatry
- Women's Health
Background:
- Affective illness is prevalent in women, particularly during the vulnerable puerperium period.
- Hormonal shifts, socialization, and genetics contribute to gender differences in affective disorder expression.
- Postpartum depression (PPD) complicates 15% of deliveries, with significant risk factors identified.
Purpose of the Study:
- To highlight the vulnerability of women to affective illness postpartum.
- To examine the effectiveness of screening tools in increasing treatment seeking for perinatal depression.
- To underscore the adverse outcomes of untreated maternal depression on both mother and child.
Main Methods:
- Review of existing literature on postpartum depression and screening tools.
- Analysis of factors influencing treatment seeking in pregnant and postpartum women.
- Examination of complications associated with untreated depression during pregnancy.
Main Results:
- Screening tools like the Edinburgh Postpartum Depression Scale can identify women needing further assessment.
- Despite identification, only 18% of women with major depressive disorder seek treatment during pregnancy and postpartum.
- Common depression symptoms may be mistaken for normal pregnancy experiences, hindering diagnosis.
Conclusions:
- Untreated antenatal and postpartum depression can lead to adverse pregnancy outcomes, including low birth weight and premature birth.
- Perceived stress, depression, and anxiety are linked to poorer infant outcomes.
- Effective treatment engagement is crucial for improving maternal and child health, despite challenges in identifying and treating PPD.
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