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Trophic action of epidermal growth factor on human duodenal mucosa cultured in vitro
1Somerset Children's Research Unit, Musgrove Park Hospital, Taunton.
Gut
|September 1, 1991
Abstract:
The action of epidermal growth factor on the human duodenal mucosa has been studied by estimating the crypt cell production rate in cultured explants, using a stathmokinetic technique with crypt microdissection. The addition of epidermal growth factor (400 ng/ml) to paired explants from five patients caused an almost fivefold increase in the crypt cell production rate, showing that epidermal growth factor has a trophic action on the human duodenal mucosa in vitro.

