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Vaccinations

Vaccinations

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Updated: Jun 26, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

Pertussis vaccine: a critique.

John B Robbins¹, Rachel Schneerson, Jerry M Keith

¹Fogarty International Center, National Institute of Health, Bethesda, MD 20892-2423, USA. robbinsJo@mail.nih.gov

The Pediatric Infectious Disease Journal

|January 24, 2009

Summary

A critical level of serum IgG pertussis toxin antibody is essential for immunity. Monocomponent pertussis toxoid provides this immunity, refuting the need for additional vaccine components.

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Area of Science:

Immunology
Vaccinology
Microbiology

Background:

Pertussis (whooping cough) remains a public health concern.
Current pertussis vaccines are multicomponent, but their efficacy is debated.
The role of specific antibodies in conferring immunity is crucial.

Purpose of the Study:

To determine the essential and sufficient antibody level for pertussis immunity.
To evaluate the contribution of individual components in multicomponent pertussis vaccines.
To compare the safety and immunogenicity of genetically-inactivated mutant pertussis toxoid with current vaccines.

Main Methods:

Analysis of serum IgG pertussis toxin antibody levels.
Review of vaccination data from Sweden and Denmark.
Critique of efficacy estimation methods for multicomponent vaccines.

Main Results:

A critical level of serum IgG pertussis toxin antibody is sufficient for individual and herd immunity.
Monocomponent pertussis toxoid successfully conferred immunity in Sweden and Denmark.
Filamentous hemagglutinin, pertactin, and fimbriae do not add to immunity conferred by pertussis toxoid.

Conclusions:

Pertussis toxin antibody levels are the key determinant of immunity.
Monocomponent pertussis toxoid vaccines are effective and sufficient.
Genetically-inactivated mutant pertussis toxoid offers a safer, more immunogenic, and potentially more effective alternative.