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Updated: Jun 26, 2026

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish
Published on: June 7, 2018
Direct effects of doxorubicin on skeletal muscle contribute to fatigue
K van Norren1, A van Helvoort, J M Argilés
1Danone Research, Centre for Specialised Nutrition (formerly known as Numico Research), Wageningen, The Netherlands. Klaske.vanNorren@Danone.com
Abstract:
Chemotherapy-induced fatigue is a multidimensional symptom. Oxidative stress has been proposed as a working mechanism for anthracycline-induced cardiotoxicity. In this study, doxorubicin (DOX) was tested on skeletal muscle function. Doxorubicin induced impaired ex vivo skeletal muscle relaxation followed in time by contraction impediment, which could be explained by DOX-induced changes in Ca(2+) responses of myotubes in vitro. The Ca(2+) responses in skeletal muscle, however, could not be explained by oxidative stress.
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