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Genetic thrombophilia variants and risk for preeclampsia among American Indians
Lyle G Best1, Sheri T Dorsam, Melanie Nadeau
1Turtle Mountain Community College, Belcourt, North Dakota, USA. sbest@utma.com
Objective:
To determine the prevalence of thrombophilic genetic variants in an American Indian population and determine if they are associated with preeclampsia.
Methods:
A total of 87 cases, 165 controls and an additional 75 population-based controls were genotyped for two thrombophilic polymorphisms.
Results:
The allelic prevalence of the factor V Leiden and 20210 G/A prothrombin variants in this population was 2.1% and 0.5% respectively. No statistically significant associations between these genetic variants and preeclampsia were found.
Conclusion:
The prevalence of thrombophilic variants is of possible public health significance for other morbidity; but perhaps not in relation to preeclampsia.
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