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Updated: Jun 26, 2026

Characterization of Synthetic Polymers via Matrix Assisted Laser Desorption Ionization Time of Flight (MALDI-TOF) Mass Spectrometry
Published on: June 10, 2018
Imaging mass spectrometry for examining localization of polymeric composition in matrix-assisted laser
Steffen M Weidner1, Jana Falkenhagen
1Federal Institute for Materials Research and Testing (BAM), Department I, Richard-Willstaetter-Strasse 11, D-12489 Berlin, Germany. steffen.weidner@bam.de
Abstract:
The localization of polymeric composition in samples prepared for matrix-assisted laser desorption/ionization (MALDI) analysis has been investigated by imaging mass spectrometry. Various matrices and solvents were used for sample spot preparation of a polybutyleneglycol (PBG 1000). It was shown that in visibly homogeneous spots, prepared using the 'dried droplet' method, separation between matrix and polymer takes place. Moreover, using alpha-cyano-4-hydroxycinnamic acid (CCA) as matrix and methanol as solvent molecular mass separation of the polymer homologues in the spots was detectable. In contrast to manually spotted samples, dry spray deposition results in homogeneous layers showing no separation effects.
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