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[Glucocorticoid therapy in childhood]
1Endokrinologische Abteilung Kinderklinik, Dr. von Haunerschen Kinderspital, Universität München.
Fortschritte Der Medizin
|August 10, 1991
Summary
Glucocorticoid therapy is sometimes needed in children for conditions like adrenogenital syndrome and respiratory distress syndrome. Potential side effects include adrenal suppression and growth issues.
Area of Science:
- Pediatric Endocrinology
- Pharmacology
- Neonatology
Context:
- Glucocorticoids are essential medications in pediatric care, used for specific endocrine disorders and various other conditions.
- Their application extends from replacement therapy in congenital adrenal hyperplasia to managing critical illnesses in neonates.
Purpose:
- To outline the indications for glucocorticoid use in pediatric patients.
- To detail the therapeutic applications in both endocrine and non-endocrine pediatric diseases.
- To highlight potential adverse effects associated with glucocorticoid pharmacotherapy in children.
Summary:
- Glucocorticoid treatment is occasionally required in children for conditions such as adrenogenital syndrome and pharmacotherapy for nephrotic syndrome, autoimmune diseases, hypsarrhythmia, respiratory distress syndrome, and bronchopulmonary dysplasia.
- Key indications include replacement therapy and managing inflammatory and respiratory conditions in neonates.
- Adverse effects encompass adrenal cortical suppression, growth disturbances, truncal obesity, striae, and osteoporosis.
Impact:
- Informs clinicians about the judicious use of glucocorticoids in pediatric populations.
- Raises awareness of potential side effects, aiding in monitoring and management.
- Contributes to evidence-based guidelines for pediatric pharmacotherapy involving glucocorticoids.