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Updated: Jun 26, 2026
A Facile and Eco-friendly Route to Fabricate Poly(Lactic Acid) Scaffolds with Graded Pore Size
Published on: October 17, 2016
Porous biodegradable scaffold: predetermined porosity by dissolution of poly(ester-anhydride) fibers from polyester
Jaana Rich1, Harri Korhonen, Risto Hakala
1Polymer Technology, Department of Biotechnology and Chemical Technology, Helsinki University of Technology, P.O. Box 6100, 02015 TKK, Espoo, Finland. jaana.rich@tkk.fi
Abstract:
A novel selective leaching method for the porogenization of the biodegradable scaffolds was developed. Continuous, predetermined pore structure was prepared by dissolving fast eroding poly(epsilon-caprolactone)-based poly(ester-anhydride) fibers from the photo-crosslinked poly(epsilon-caprolactone) matrix. The porogen fibers dissolved in the phosphate buffer (pH 7.4, 37 degrees C) within a week, resulting in the porosity that replicated exactly the single fiber dimensions and the overall arrangement of the fibers. The amount of the porosity, estimated with micro-CT, corresponded with the initial amount of the fibers. The potential to include bioactive agents in the porogen fibers was demonstrated with the bioactive glass.
