Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

Modified-Release Drug Delivery Systems: Site-Targeted

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...

Cellular Membranes and Drug Transport

Cellular Membranes and Drug Transport

Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.

Biopharmaceutical Factors Influencing Drug Product Design: Overview

Biopharmaceutical Factors Influencing Drug Product Design: Overview

Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though pharmacologically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Synthesis and Pharmacological Characterization of Novel Peripheral Cannabinoid-1 Receptor Blockers Based on a Tricyclic Scaffold.

Journal of medicinal chemistry·2025

Same author

Correction: Novel targeted mtLivin nanoparticles treatment for disseminated diffuse large B-cell lymphoma.

Oncogene·2025

Same author

Effect of cyclosporine A - tempol topical gel for the treatment of alopecia and anti-inflammatory disorders.

International journal of pharmaceutics·2023

Same author

The dose-dependent effect of a stabilized cannabidiol nanoemulsion on ocular surface inflammation and intraocular pressure.

International journal of pharmaceutics·2022

Same author

Biodistribution and efficacy of the anticancer drug, oxaliplatin palmitate acetate, in mice.

International journal of pharmaceutics·2021

Same author

Topical tacrolimus nanocapsules eye drops for therapeutic effect enhancement in both anterior and posterior ocular inflammation models.

Journal of controlled release : official journal of the Controlled Release Society·2021

Search research articles

Related Experiment Video

Updated: Jun 26, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Nanoparticle-cell interactions: drug delivery implications.

Oshrat Harush-Frenkel¹, Yoram Altschuler, Simon Benita

¹Department of Pharmaceutics and Pharmacology, The Hebrew University of Jerusalem, 91120, Israel.

Critical Reviews in Therapeutic Drug Carrier Systems

|January 27, 2009

Summary

This review explores nanoparticle uptake via endocytosis for targeted drug delivery. It details cellular pathways, nanoparticle properties, and methods for studying intracellular trafficking in different cell types.

More Related Videos

Experimental Quantification of Interactions Between Drug Delivery Systems and Cells In Vitro: A Guide for Preclinical Nanomedicine Evaluation

Experimental Quantification of Interactions Between Drug Delivery Systems and Cells In Vitro: A Guide for Preclinical Nanomedicine Evaluation

Published on: September 28, 2022

Related Experiment Videos

Last Updated: Jun 26, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Experimental Quantification of Interactions Between Drug Delivery Systems and Cells In Vitro: A Guide for Preclinical Nanomedicine Evaluation

Experimental Quantification of Interactions Between Drug Delivery Systems and Cells In Vitro: A Guide for Preclinical Nanomedicine Evaluation

Published on: September 28, 2022

Area of Science:

Biomedical Engineering
Cell Biology
Nanotechnology

Background:

Targeted drug delivery to specific cellular organelles remains a significant challenge.
Endocytosis pathways are crucial for cellular uptake but are complex and vary between cell types.
Understanding nanoparticle internalization is key to developing effective nanomedicines.

Purpose of the Study:

To review endocytosis machineries and pathways involved in nanoparticle internalization.
To compare nanoparticle uptake in polarized epithelial versus nonpolarized cells.
To discuss the influence of nanoparticle physicochemical properties and experimental tools on cellular entry.

Main Methods:

Literature review of endocytosis mechanisms.
Analysis of nanoparticle-cell interactions.
Comparison of uptake in different cellular models.
Discussion of analytical techniques for nanoparticle tracking.

Main Results:

Endocytic pathways exhibit significant differences between polarized and nonpolarized cells.
Physicochemical properties of nanoparticles critically affect their cellular internalization.
Various experimental tools are available to study nanoparticle uptake and trafficking.
Current strategies for organelle-specific drug delivery via endocytosis are still nascent.

Conclusions:

A comprehensive understanding of endocytosis is vital for designing efficient nanoparticulate drug delivery systems.
Cell-type specific differences in endocytosis must be considered for targeted delivery.
Further research is needed to optimize nanoparticle design and delivery strategies for intracellular targeting.