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Related Experiment Videos

Hepatorenal reflex regulating kidney function.

F Lang1, E Tschernko, E Schulze

  • 1Institute for Physiology, University of Innsbruck, Austria.

Hepatology (Baltimore, Md.)
|October 1, 1991
PubMed
Summary
This summary is machine-generated.

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[Not Available].

Zeitschrift fur Gastroenterologie·2015

Liver cell swelling from glutamine infusion into the mesenteric vein reduces kidney function in rats. This effect is mediated by the hepatorenal innervation, highlighting a liver-kidney regulatory pathway.

Area of Science:

  • Physiology
  • Nephrology
  • Gastroenterology

Background:

  • Liver cell swelling can impact systemic functions.
  • The liver and kidneys have complex interconnections.
  • Innervation pathways between organs are crucial for regulation.

Purpose of the Study:

  • To investigate the effect of liver cell swelling induced by glutamine on kidney function in rats.
  • To identify the neural pathways mediating the liver-kidney interaction.
  • To explore the role of glucagon in this regulatory mechanism.

Main Methods:

  • Infusion of glutamine into the superior mesenteric vein and jugular vein in anesthetized male rats.
  • Measurement of renal glomerular filtration rate, para-aminohippurate clearance, and urinary flow rate.

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  • Surgical interventions including spinal transection, renal denervation, and vagal hepatic nerve section.

    • Main Results:

    • Mesenteric glutamine infusion significantly decreased renal function and urinary flow.
    • Jugular glutamine infusion did not produce these effects.
    • Serine mimicked glutamine's effect, but glutamate did not.
    • Spinal transection, renal denervation, or vagal hepatic nerve section abolished the effect.
    • Mesenteric glucagon, alone or with glutamine, enhanced renal function and urinary flow.

    Conclusions:

    • A potent liver-borne mechanism regulates kidney function via hepatorenal innervation.
    • Glutamine-induced liver cell swelling triggers this regulatory pathway.
    • The hepatorenal innervation is critical for mediating these liver-kidney signals.