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Related Concept Videos

Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Lampbrush Chromosomes01:51

Lampbrush Chromosomes

In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops resemble the...
Lampbrush Chromosomes01:51

Lampbrush Chromosomes

In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops resemble the...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

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Related Experiment Video

Updated: Jun 26, 2026

Mapping Mammalian 3D Genome Interactions with Micro-C-XL
11:41

Mapping Mammalian 3D Genome Interactions with Micro-C-XL

Published on: November 3, 2023

Genome Projector: zoomable genome map with multiple views.

Kazuharu Arakawa1, Satoshi Tamaki, Nobuaki Kono

  • 1Institute for Advanced Biosciences, Keio University, Fujisawa, 252-8520, Japan. gaou@sfc.keio.ac.jp

BMC Bioinformatics
|January 27, 2009
PubMed
Summary
This summary is machine-generated.

Genome Projector offers an intuitive web interface for exploring genomics data across multiple scales and views. This zoomable user interface utilizes Google Maps API for seamless navigation of bacterial genome information.

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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers
08:12

A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers

Published on: July 18, 2025

Related Experiment Videos

Last Updated: Jun 26, 2026

Mapping Mammalian 3D Genome Interactions with Micro-C-XL
11:41

Mapping Mammalian 3D Genome Interactions with Micro-C-XL

Published on: November 3, 2023

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers
08:12

A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers

Published on: July 18, 2025

Area of Science:

  • Genomics
  • Bioinformatics
  • Computational Biology

Background:

  • Molecular biology data span multiple scales, from molecules to -omics.
  • Biological data are multi-layered (genome, transcriptome, proteome, metabolome, pathways).
  • Intuitive interfaces are crucial for navigating complex, multi-dimensional biological information.

Purpose of the Study:

  • To develop an intuitive web-based gateway for genomics information.
  • To enable rapid migration across different views and scales of biological data.
  • To leverage Zoomable User Interface (ZUI) and tabbed browsing for enhanced data exploration.

Main Methods:

  • Implementation of a Web application named Genome Projector.
  • Utilizing Google Maps API for a zoomable user interface (ZUI).
  • Integration of Asynchronous JavaScript and XML (AJAX) technology for dynamic content loading.

Main Results:

  • Genome Projector provides four seamlessly accessible and searchable views: circular genome map, traditional genome map, biochemical pathways map, and DNA walk map.
  • The web application supports 320 bacterial genomes.
  • Freely available data, source code, documentation, and development API under GNU GPL.

Conclusions:

  • Genome Projector is an intuitive web application for browsing genomics information.
  • The application effectively uses ZUI and tabbed browsing with Google Maps API and AJAX.
  • Zoomable maps can be created from any image file using the provided development API.