Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Liver Histology01:27

Liver Histology

The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How to Identify and Treat MetALD.

Gastroenterology & hepatology·2026
Same author

A multisociety consensus statement on a new common definition and diagnostic criteria for PSVD or NCPF.

Hepatology international·2026
Same author

A multisociety consensus statement on a new common definition and diagnostic criteria for PSVD or NCPF.

Hepatology (Baltimore, Md.)·2026
Same author

A multisociety consensus statement on a new common definition and diagnostic criteria for PSVD or NCPF.

Annals of hepatology·2026
Same author

A multisociety consensus statement on a new common definition and diagnostic criteria for PSVD or NCPF.

Journal of hepatology·2026
Same author

Slide-free, point-of-care imaging of core needle biopsies for rapid histologic assessment.

Biomedical optics express·2026

Related Experiment Video

Updated: Jun 26, 2026

Selective Harvesting of Marginating-hepatic Leukocytes
06:53

Selective Harvesting of Marginating-hepatic Leukocytes

Published on: July 21, 2016

Granulomatous liver disease.

Sidharth S Bhardwaj1, Romil Saxena, Paul Y Kwo

  • 1Division of Gastroenterology/Hepatology, 975 West Walnut Street, IB 327, Indianapolis, IN 46202-5121, USA. pkwo@iupui.edu

Current Gastroenterology Reports
|January 27, 2009
PubMed
Summary

Hepatic granulomas found during liver biopsy require clinical correlation for accurate diagnosis. Management strategies range from targeted therapy to observation, depending on the underlying cause.

Area of Science:

  • Hepatology
  • Immunology
  • Pathology

Background:

  • Hepatic granulomas are inflammatory responses in the liver, frequently identified during liver biopsies.
  • They can indicate primary liver disease, systemic conditions, or be incidental findings.
  • Causes include infections, drug toxicity, and malignancy.

Purpose of the Study:

  • To emphasize the importance of correlating liver biopsy findings with clinical data.
  • To guide accurate diagnosis and management of hepatic granulomas.
  • To discuss therapeutic and observational approaches.

Main Methods:

  • Histopathological examination of liver biopsies.
  • Correlation of histological findings with patient history and clinical presentation.

More Related Videos

Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques
11:06

Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques

Published on: May 2, 2017

Related Experiment Videos

Last Updated: Jun 26, 2026

Selective Harvesting of Marginating-hepatic Leukocytes
06:53

Selective Harvesting of Marginating-hepatic Leukocytes

Published on: July 21, 2016

Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques
11:06

Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques

Published on: May 2, 2017

  • Review of diagnostic and therapeutic strategies.

    • Main Results:

    • Hepatic granulomas necessitate a comprehensive diagnostic approach.
    • Differential diagnoses are broad, including infectious, inflammatory, and neoplastic processes.
    • Clinical correlation is crucial for determining the significance of granulomas.

    Conclusions:

    • Accurate diagnosis of hepatic granulomas relies on integrating biopsy results with clinical information.
    • Management decisions should be individualized based on the etiology and clinical context.
    • Therapy may target the granulomatous inflammation or the underlying systemic disease.