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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...

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Related Experiment Video

Updated: Jun 26, 2026

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
06:32

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

Methods for the measurement of platelet function.

Alan D Michelson1

  • 1Center for Platelet Function Studies, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

The American Journal of Cardiology
|January 27, 2009
PubMed
Summary
This summary is machine-generated.

Monitoring antiplatelet activity is crucial for cardiovascular disease patients. This review compares various platelet function tests to assess their effectiveness in predicting thrombosis and bleeding risks.

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Last Updated: Jun 26, 2026

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
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Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Clinical Pathology

Background:

  • Platelet function tests are essential for managing antiplatelet therapy in cardiovascular disease.
  • Monitoring antiplatelet activity helps predict risks of thrombosis and bleeding.

Purpose of the Study:

  • To review and compare various methods for measuring platelet function.
  • To evaluate the utility of these tests in monitoring antiplatelet therapy and predicting clinical outcomes.

Main Methods:

  • The article discusses multiple platelet function measurement techniques.
  • These include aggregometry, impedance aggregometry, and specific assays like VerifyNow and Plateletworks.
  • Other methods evaluated involve flow cytometry markers (P-selectin, activated glycoprotein IIb/IIIa, leukocyte-platelet aggregates), TEG Platelet Mapping, Impact cone and plate analyzer, and Platelet Function Analyzer-100.
  • Biochemical markers such as serum thromboxane B2 and urinary 11-dehydro thromboxane B2 are also considered.

Main Results:

  • Different tests vary in sample volume, use of whole blood, shear stress simulation, point-of-care capability, technical requirements, and cost.
  • The choice of test depends on specific clinical needs and available resources.

Conclusions:

  • A range of platelet function tests are available, each with distinct advantages and disadvantages.
  • Selecting the appropriate test is critical for effective patient management in cardiovascular disease.