Increased -1 ribosomal frameshifting efficiency by yeast prion-like phenotype [PSI+]
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Updated: Jun 26, 2026

High-throughput Screening for Protein-based Inheritance in S. cerevisiae
Published on: August 8, 2017
Hee Jung Park1, So Jung Park, Doo-Byoung Oh
1Department of Chemistry, School of Natural Sciences, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
Abstract:
Programmed -1 ribosomal frameshifting (-1RF) is usually regulated by a slippery sequence and an RNA secondary structure but can be affected by the slippery sequence combined with translational perturbation. Dramatic increases of -1RF efficiencies arise from the slippery sequences in [PSI+], an epigenetic modifier of translation termination fidelity. Curing of [PSI+] abolished such increases of -1RF efficiency. Enhanced -1RF frequency at the slippery sequences could be another physiological effect induced directly or indirectly by the perturbation of the translation process in [PSI+] cells.
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