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Activation of toll-like receptor-3 induces interferon-lambda expression in human neuronal cells

L Zhou1, X Wang, Y J Wang

  • 1Division of Allergy and Immunology, Joseph Stokes, Jr. Research Institute at The Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Neuroscience
|January 27, 2009
PubMed
Summary

Human neuronal cells express and regulate type III interferon-lambda (IFN-lambda), a key antiviral protein. This innate immune response in neurons offers protection against viral infections in the central nervous system (CNS).

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