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Induction of Ocular Surface Inflammation and Collection of Involved Tissues
06:38

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Published on: August 4, 2022

Contact lens wear is associated with decrease of meibomian glands.

Reiko Arita1, Kouzo Itoh, Kenji Inoue

  • 1Itoh Clinic, Saitama, Japan. ritoh@za2.so-net.ne.jp

Ophthalmology
|January 27, 2009
PubMed
Summary
This summary is machine-generated.

Contact lens wear significantly reduces meibomian gland function, with longer wear duration correlating to greater gland loss. This finding is crucial for understanding and managing contact lens-related dry eye disease.

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Area of Science:

  • Ophthalmology
  • Optometry
  • Dry Eye Disease Research

Background:

  • Dry eye symptoms affect 30-50% of contact lens (CL) wearers.
  • Meibomian gland dysfunction (MGD) is a suspected cause of CL-related dry eye.
  • A novel meibographic technique was employed to assess meibomian gland health.

Purpose of the Study:

  • To investigate the impact of contact lens wear on meibomian gland structure.
  • To quantify meibomian gland loss in contact lens wearers compared to non-wearers.

Main Methods:

  • A cross-sectional observational study included 121 contact lens wearers and 137 healthy volunteers.
  • Evaluations included slit-lamp examination, corneal staining, tear film breakup time, Schirmer I test, and noncontact meibography.
  • Meibomian gland loss was quantified using a 4-grade meiboscore, summed for upper and lower eyelids.

Main Results:

  • Contact lens wearers exhibited significantly higher meiboscores (mean 1.72) than the control group (mean 0.96) (P<0.0001).
  • The meiboscore in contact lens wearers resembled that of individuals aged 60-69 in the general population.
  • A positive correlation was found between the duration of contact lens wear and meiboscore.

Conclusions:

  • Contact lens wear is associated with a reduction in functional meibomian glands.
  • The degree of meibomian gland loss is directly proportional to the duration of contact lens wear.
  • These findings highlight the detrimental effect of prolonged contact lens use on ocular surface health.