Novel homo-bimetallic complexes of [N(10)] macrocyclic ligand modified with tetrapeptide function: biological
Zafar A Siddiqi1, Sarvendra Kumar, Mohd Khalid
1Coordination Chemistry Research Group, Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India. zafarsiddiqi@yahoo.co.in
Abstract:
The bimetallic complexes [M(2)LCl(4)] (M=Cr, Co, Ni, Cu) prepared via metal template cyclization reactions were characterized by physico-chemical and spectroscopic methods. L is a 30-membered [N(10)] macrocycle with tetraamide functions bind metal ions through aza donors forming hexa-coordinate geometry. The perspective view and important structural parameters have been computed from the molecular model (MOPAC) method. The electrochemical studies indicate existence of quasi-reversible redox couples in solution. The metal complexes were screened (in vitro) against a few pathogenic fungi and bacteria to assess their growth inhibiting potential.
Related Concept Videos
00:43Complexometric Titration: Ligands
02:51Metal-Ligand Bonds
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
02:42Valence Bond Theory
01:22EDTA: Chemistry and Properties
01:19Complexation Equilibria: The Chelate Effect
02:34Structural Isomerism
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can be...