Related Experiment Video

Updated: Jun 26, 2026

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

Association between cardiac function and metabolic factors including adiponectin in patients with acute myocardial

Kumi Kimura1, Shin-ichiro Miura, Atsushi Iwata

  • 1Department of Cardiology, Fukuoka University School of Medicine, Jonan-Ku, Fukuoka, Japan.

Journal of Cardiology
|January 27, 2009
PubMed

Insights

In patients with acute myocardial infarction (AMI), higher adiponectin levels one week after treatment predict worse cardiac function six months later. This finding highlights adiponectin as a key metabolic marker for predicting heart recovery post-AMI.

Area of Science:

  • Cardiology
  • Metabolic Syndrome
  • Biomarkers

Background:

  • Limited understanding of metabolic factors, including adiponectin, and cardiac function post-acute myocardial infarction (AMI).
  • Previous studies focused on chronic heart failure, not acute events.

Purpose of the Study:

  • To investigate the relationship between cardiac function and metabolic factors, specifically adiponectin, in patients following AMI.
  • To identify predictors of cardiac dysfunction at 6 months post-AMI.

Main Methods:

  • Analysis of 50 consecutive AMI patients post-stent implantation.
  • Echocardiography and blood sampling at 1 week and 6 months post-AMI.
  • Measurement of brain natriuretic peptide (BNP), adiponectin, lipid profile, and HbA1c.

Main Results:

  • Plasma adiponectin levels increased significantly from 1 week to 6 months post-AMI.
  • Brain natriuretic peptide (BNP) levels significantly decreased over the same period.
  • Higher baseline adiponectin at 1 week strongly correlated with higher BNP levels at 6 months, indicating poorer cardiac function.

Conclusions:

  • Elevated plasma adiponectin levels at 1 week post-AMI predict higher BNP levels at 6 months.
  • Adiponectin emerges as a significant metabolic predictor of cardiac dysfunction following acute myocardial infarction.
Abstract

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...