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Familial aggregation of IgAD and autoimmunity
Gudmundur H Jorgensen1, Ingunn Thorsteinsdottir, Sveinn Gudmundsson
1Department of Medicine, University of Iceland, Reykjavík, Iceland.
Background:
The prevalence of autoimmunity is thought to be increased among IgA deficient (IgAD) individuals. However, it is currently unclear if the two conditions coincide within families.
Objective:
To evaluate the prevalence of autoimmunity among IgAD individuals and their 1 degrees relatives.
Material And Methods:
A total of 43 IgAD individuals (32 adults and 11 children) and all available 1 degrees relatives were evaluated by a physician. A family history of autoimmunity was obtained, together with physical examination and a structured questionnaire that focused on symptoms and signs suggestive of autoimmunity.
Results:
Eight of the 32 (25%) adult IgAD, were found to have definite autoimmunity, with organ specific- and systemic autoimmune diseases equally distributed. None of the IgAD children had autoimmunity. Among the 1 degrees relatives, 27/269 (10%) had autoimmunity, compared to an estimate of 5% in the general population (p<0.05).
Conclusion:
Autoimmune diseases are highly prevalent in individuals with IgAD and more common in their 1 degrees relatives than expected, thus, suggesting a possible common genetic component.
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