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Deep gray matter atrophy in multiple sclerosis: a tensor based morphometry.

Guozhi Tao1, Sushmita Datta, Renjie He

  • 1Department of Diagnostic and Interventional Imaging, University of Texas Medical School at Houston, Houston, TX 77030, USA.

Journal of the Neurological Sciences
|January 27, 2009
PubMed
Summary
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Tensor-based morphometry reveals significant deep gray matter atrophy in multiple sclerosis (MS) patients, correlating with disability and white matter damage. This atrophy impacts key structures like the thalamus, even in early stages of the disease.

Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Multiple Sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system.
  • Deep gray matter (DGM) structures are crucial for neurological function and are increasingly recognized as affected in MS.
  • Understanding DGM atrophy patterns is vital for assessing disease progression and disability.

Purpose of the Study:

  • To quantify deep gray matter (DGM) atrophy in relapsing-remitting multiple sclerosis (MS) patients using tensor-based morphometry (TBM).
  • To investigate the correlation between DGM atrophy and clinical disability (Expanded Disability Status Score - EDSS).
  • To explore the relationship between DGM atrophy and white matter damage, including T2 and T1 lesion volumes and cerebrospinal fluid (CSF) volume.

Main Methods:

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  • Applied tensor-based morphometry (TBM) to analyze brain images of 88 relapsing-remitting MS patients.
  • Constructed an unbiased atlas from 20 healthy brains for group analysis.
  • Utilized symmetric, inverse-consistent, nonlinear registration to co-register MS brain images with the atlas.

Main Results:

  • Significant atrophy was detected in the thalamus, caudate nucleus, and putamen, even with mild clinical disability (EDSS).
  • Atrophy in these DGM structures showed significant negative correlations with EDSS scores.
  • DGM atrophy was also significantly correlated with T2 hyperintense lesion volume, T1 hypointense lesion volume, and normalized CSF volume.

Conclusions:

  • Deep gray matter (DGM) atrophy, particularly in the thalamus, is a significant feature of relapsing multiple sclerosis (MS), correlating with clinical disability.
  • The findings suggest a link between white matter damage and DGM atrophy in MS patients.
  • TBM is a valuable tool for quantifying DGM changes and their relationship to disease severity in MS.