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[Uveitis: occurrence in rheumatic diseases and immunosuppressive therapy]
M Schwarz-Eywill1, A Breitbart, A Pezzutto
1Medizinische Klinik V und Poliklinik, Universität Heidelberg.
Immunitat Und Infektion
|June 1, 1991
Summary
Rheumatic conditions are frequently linked to uveitis, an inflammatory eye disease. Methotrexate effectively treated steroid-resistant noninfectious uveitis, with some patients achieving full remission.
Area of Science:
- Ophthalmology
- Rheumatology
- Immunology
Background:
- Uveitis, a group of inflammatory eye conditions, can be associated with systemic rheumatic diseases.
- Identifying the etiology of uveitis is crucial for effective management.
- Steroids are a common treatment but may not be sufficient for all cases.
Purpose of the Study:
- To investigate the prevalence of associated rheumatic conditions in uveitis patients.
- To evaluate the efficacy of methotrexate in noninfectious uveitis refractory to steroids.
Main Methods:
- Retrospective analysis of 53 uveitis patients.
- Assessment for associated rheumatic conditions.
- Treatment with methotrexate for steroid-refractory noninfectious uveitis.
Main Results:
- A rheumatic condition was identified in 13 out of 53 patients.
- An infectious cause was suspected in 3 patients.
- All 11 patients treated with methotrexate showed improvement, with 5 achieving complete remission.
Conclusions:
- Rheumatic diseases are a significant comorbidity in uveitis.
- Methotrexate is a promising therapeutic option for refractory noninfectious uveitis.