Related Experiment Video

Updated: Jun 26, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Clinical characteristics of benign convulsions with rotavirus gastroenteritis

Masashi Motoyama1, Takashi Ichiyama, Takeshi Matsushige

  • 1Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.

Journal of Child Neurology
|January 27, 2009
PubMed

Insights

Carbamazepine effectively treated benign convulsions in infants with rotavirus gastroenteritis. This treatment showed a high success rate, with most patients experiencing no further seizures after administration.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Neurology

Background:

  • Gastroenteritis, particularly rotavirus infections, can precipitate convulsions in young children.
  • The specific characteristics and management of these convulsions require further investigation.

Purpose of the Study:

  • To investigate the clinical features of convulsions associated with rotavirus gastroenteritis in infants and toddlers.
  • To evaluate the efficacy of carbamazepine in managing benign convulsions linked to rotavirus gastroenteritis.

Main Methods:

  • Retrospective analysis of hospital records for 106 patients with rotavirus gastroenteritis (February 2002 - April 2008).
  • Categorization of convulsion types (benign, febrile seizures, epilepsy) and comparison of clinical parameters (body weight, serum creatinine, electrolytes) between groups.
  • Assessment of carbamazepine treatment outcomes in patients with benign convulsions.

Main Results:

  • Twenty-three out of 106 patients experienced convulsions; 13 had benign convulsions.
  • Patients with benign convulsions exhibited milder gastroenteritis symptoms and lower serum sodium and chloride levels upon admission.
  • Carbamazepine (5 mg/kg) was effective in 12 out of 13 patients with benign convulsions, preventing further seizures.

Conclusions:

  • Benign convulsions associated with rotavirus gastroenteritis are characterized by milder illness and electrolyte imbalances.
  • Carbamazepine demonstrates significant efficacy in treating benign convulsions secondary to rotavirus gastroenteritis in pediatric patients.

More Related Videos

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale07:35

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Published on: July 8, 2025

Related Concept Videos

Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Seizures l: Introduction01:20

Seizures l: Introduction

Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...
Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through interaction...