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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
HS071, a new furan-type cytotoxic metabolite from Streptomyces sp. HS-HY-071
Jidong Wang1, Hui Zhang, Xiaohu Yang
1Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou, Zhejiang, China.
The Journal of Antibiotics
|January 27, 2009
Abstract:
Investigation of the bioactive metabolites from the soil-derived actinomycete, Streptomyces sp. HS-HY-071, a new furan-type antibiotic, HS071 (1), was isolated. Its structure was established as methyl 4-hydroxymethyl-2-pentylfuran-3-carboxylate on the basis of extensive 1D and 2D NMR and MS spectral analysis. It exhibited in vitro activity against HCT-116 cell with an IC50 of 18.2 microg/ml.
