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Body fat in men with prolactinoma
E C O Naliato1, A H D Violante, M Gaccione
1Division of Endocrinology, Department of Internal Medicine, Federal University of Rio de Janeiro (UFRJ), Hyperprolactinemia Unit, Clementino Fraga Filho University Hospital (HUCFF), Rio de Janeiro, Brazil. erikanaliato@uol.com.br
Journal of Endocrinological Investigation
|January 27, 2009
Summary
Newly-diagnosed men with prolactinoma exhibit increased body fat, particularly in the arms and total body. This body fat is linked to prolactin and androgen levels, highlighting the importance of managing hyperprolactinemia to prevent obesity complications.
Area of Science:
- Endocrinology
- Metabolic Health
- Body Composition Analysis
Background:
- Prolactinoma, a condition of excess prolactin, can affect male health.
- Understanding body composition in men with prolactinoma is crucial for metabolic health.
- Previous studies have not fully elucidated the relationship between prolactinoma and body fat distribution.
Purpose of the Study:
- To assess body fat percentage in men with prolactinoma compared to healthy controls using dual-energy x-ray absorptiometry (DXA).
- To correlate body fat measurements with anthropometric data and clinical markers in male prolactinoma patients.
Main Methods:
- A cross-sectional study involving newly-diagnosed men with prolactinoma, men treated with dopamine agonists, and healthy controls.
- Whole-body DXA scans were performed to measure body fat distribution.
- Blood analyses included prolactin, testosterone, dihydrotestosterone, estradiol, and SHBG levels.
Main Results:
- Newly-diagnosed men with prolactinoma showed significantly higher total body and arm fat percentages compared to treated patients and controls.
- Higher leg fat percentage was observed in newly-diagnosed prolactinoma patients versus controls.
- Fat percentage at various sites correlated with prolactin and androgen levels.
Conclusions:
- Men with newly-diagnosed prolactinoma have increased body fat content.
- Body fat levels are associated with disease control, specifically prolactin and androgen levels.
- Effective management of hyperprolactinemia is recommended to mitigate obesity risks and associated metabolic complications.
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