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Performing Colonoscopic-Guided Pinch Biopsies in Mice and Evaluating Subsequent Tissue Changes

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Microscopic colitis: an update.

Vikram Tangri¹, Nilesh Chande

¹Department of Medicine, The University of Western Ontario, Canada. vtangri2008@meds.uwo.ca

Journal of Clinical Gastroenterology

|January 27, 2009

Summary

This summary is machine-generated.

Microscopic colitis (MC) is a common cause of chronic diarrhea, often missed on endoscopy. Biopsies reveal specific changes, and budesonide is the most effective treatment, though others show promise.

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Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation

Published on: December 15, 2017

Area of Science:

Gastroenterology
Pathology

Background:

Microscopic colitis (MC) presents with chronic diarrhea, cramping, nausea, and weight loss.
Endoscopic examination of the colonic mucosa appears normal in MC.
Biopsies reveal characteristic abnormalities: intraepithelial lymphocytosis (lymphocytic colitis) or a thickened subepithelial collagen band (collagenous colitis).

Purpose of the Study:

To summarize the current understanding of microscopic colitis, including its epidemiology, pathophysiology, and treatment.
To highlight MC as an increasingly recognized cause of chronic diarrhea.

Main Methods:

Review of epidemiological data on MC prevalence.
Analysis of pathological findings in colonic biopsies.
Evaluation of recent research on MC pathophysiology.
Assessment of treatment efficacy studies.

Main Results:

MC is a more frequent cause of diarrhea than previously recognized.
Distinct histological features differentiate subtypes of MC.
Budesonide has emerged as the most effective treatment for MC.
Other therapeutic options also demonstrate potential benefits.

Conclusions:

Microscopic colitis requires histological confirmation due to normal endoscopic appearance.
Understanding risk factors and pathophysiology is crucial for managing MC.
Budesonide offers a promising therapeutic avenue for patients with microscopic colitis.