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Updated: Jun 26, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Granuloma annulare.

S Goucha¹, A Khaled, M Kharfi

¹Department of Dermatology, Charles Nicolle hospital of Tunis, Tunisia.

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Societa Italiana Di Dermatologia E Sifilografia

|January 27, 2009

Summary

This summary is machine-generated.

Granuloma annulare (GA) is a skin disease with varied clinical patterns, frequently seen in women. This study highlights common presentations and associated conditions like diabetes mellitus.

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Granulocyte-dependent Autoantibody-induced Skin Blistering

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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Area of Science:

Dermatology
Immunology
Pathology

Background:

Granuloma annulare (GA) is a common palisading granulomatous skin disease.
Characterized by annular arrangements of erythematous or flesh-colored papules.
Understanding its epidemiology and clinical patterns is crucial for management.

Purpose of the Study:

To assess the epidemiological and clinical patterns of Granuloma annulare (GA).
To evaluate the management strategies for GA.
To identify associated systemic diseases in GA patients.

Main Methods:

Retrospective study of 35 Granuloma annulare (GA) cases.
Data collected over an 11-year period (1995-2005).
Cases analyzed from the Dermatology Department of Charles Nicolle's Hospital of Tunis.

Main Results:

Localized GA (62.8%) was the most common pattern, followed by subcutaneous GA (25.7%).
Diabetes mellitus (25%) and thyroid diseases (5.7%) were frequent comorbidities in adults.
Treatments included topical steroids, hydroxychloroquine, and dapsone with varying degrees of success.

Conclusions:

The epidemiological and clinical patterns of GA in this series align with existing literature.
Subcutaneous GA presented pseudo-rheumatoid features in adults and exclusively affected children on the scalp.
Associated systemic diseases, particularly diabetes mellitus, are common in Granuloma annulare.