Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Type 2 idiopathic macular telangiectasia (MacTel2).

Journal francais d'ophtalmologie·2020
Same journal

[Subacute meningoencephalitis following intravesical BCG instillation immunotherapy].

Anales del sistema sanitario de Navarra·2026
Same journal

[Treatment with dabrafenib and trametinib in an intrahepatic cholangiocarcinoma harboring a BRAF V600E mutation].

Anales del sistema sanitario de Navarra·2026
Same journal

[Efficiency after integrating a hospital with a 'new management model'].

Anales del sistema sanitario de Navarra·2026
Same journal

[Anales del Sistema Sanitario de Navarra in 2025: Progress continues].

Anales del sistema sanitario de Navarra·2026
Same journal

Qualitative evaluation of a community intervention in educational centres: Opinion of the professionals involved.

Anales del sistema sanitario de Navarra·2026
Same journal

[Unequal impact of COVID-19 on mortality in long-term care homes across health areas of Castilla-La Mancha (Spain)].

Anales del sistema sanitario de Navarra·2026
See all related articles

Related Experiment Video

Updated: Jun 26, 2026

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice
04:36

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice

Published on: January 12, 2024

[Diabetic retinopathy].

D Aliseda Pérez de Madrid1, I Berástegui

  • 1Servicio de Oftalmología, Hospital de Navarra, Pamplona 31008, Spain. dalisedp@navarra.es

Anales Del Sistema Sanitario De Navarra
|January 27, 2009
PubMed
Summary
This summary is machine-generated.

Diabetic retinopathy, an eye complication of diabetes mellitus, involves retinal microvascular changes. This chapter details its classification and treatments, excluding macular edema, based on current research.

More Related Videos

Retinal Pathophysiological Evaluation in a Rat Model
09:11

Retinal Pathophysiological Evaluation in a Rat Model

Published on: May 6, 2022

Quantification of Diabetes-induced Adherent Leukocytes in Retinal Vasculature
05:54

Quantification of Diabetes-induced Adherent Leukocytes in Retinal Vasculature

Published on: January 24, 2025

Related Experiment Videos

Last Updated: Jun 26, 2026

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice
04:36

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice

Published on: January 12, 2024

Retinal Pathophysiological Evaluation in a Rat Model
09:11

Retinal Pathophysiological Evaluation in a Rat Model

Published on: May 6, 2022

Quantification of Diabetes-induced Adherent Leukocytes in Retinal Vasculature
05:54

Quantification of Diabetes-induced Adherent Leukocytes in Retinal Vasculature

Published on: January 24, 2025

Area of Science:

  • Ophthalmology
  • Endocrinology
  • Diabetology

Context:

  • Diabetes mellitus is a systemic metabolic disease with significant ocular complications.
  • Diabetic microangiopathy specifically targets the retina, manifesting early in the disease's progression.
  • Retinal changes correlate with disease duration and glycemic control.

Purpose:

  • To classify diabetic retinopathy based on current multicentric studies.
  • To outline treatment strategies for diabetic retinopathy, excluding macular edema.
  • To provide a comprehensive overview of retinal complications in diabetes.

Summary:

  • Diabetic microangiopathy causes retinal alterations like micro-aneurysms, exudates, hemorrhages, and vascular anomalies.
  • These lead to capillary closure, ischemia, or fluid extravasation causing edema.
  • The chapter focuses on classification and treatment, excluding macular edema.

Impact:

  • Enhances understanding of diabetic retinopathy's pathophysiology and clinical presentation.
  • Provides clinicians with evidence-based classification and treatment guidelines.
  • Aims to improve patient outcomes by detailing management strategies for diabetic eye disease.