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Updated: Jun 26, 2026

Retinal Pathophysiological Evaluation in a Rat Model
Published on: May 6, 2022
[Retinal manifestations of infectious diseases]
M Pérez de Arcelus1, A Salinas, A García Layana
1Departamento de Oftalmología, Clínica Universitaria de Navarra, Pamplona, Spain.
Abstract:
The retina and the choroids are richly vascularised structures and can therefore be colonised by germs via the haematogenous route in the course of a systemic infectious disease. The germs responsible for this type of infection can be fungi, viruses, bacteria and parasites. Ocular candidiasis is outstanding amongst these colonisations because of its frequency; it can manifest itself as an endophthalmitis with a slow and hidden course. The so-called ocular histoplasmosis syndrome, although it is infrequent in our setting, is an important cause of choroidal neovascularisation. The viruses that most frequently affect the retina are of the herpes type and can produce devastating symptoms in immunoincompetent patients, named acute retinal necrosis syndrome. Retinitis due to cytomegalovirus is more frequent in immunodepressed patients, as in the case of AIDS, but it must also be contemplated in patients with lymphoma and immunomodulatory treatment. The most frequent bacterial diseases that affect the retina are syphilis and tuberculosis. Disease due to cat scratches, caused by a borrelia, can produce a neuroretinitis. Toxoplasmosis is the most common of the infectious diseases caused by a parasite and gives rise to chorioretinitis. Toxocariasis, also caused by a parasite, is second in importance, giving rise to choroidal granulomas and retinal tractions.
Insights
Infectious diseases can affect the retina and choroid through the bloodstream. Fungi, viruses, bacteria, and parasites can cause various ocular conditions, including candidiasis and retinitis.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Context:
- The retina and choroid are highly vascularized, making them susceptible to hematogenous spread of pathogens during systemic infections.
- Ocular infections can arise from diverse microorganisms, including fungi, viruses, bacteria, and parasites.
Purpose:
- To review the spectrum of infectious agents that can colonize the retina and choroid.
- To highlight common and significant infectious causes of retinal and choroidal diseases.
Summary:
- Ocular candidiasis is a frequent fungal infection presenting as endophthalmitis.
- Viral infections like herpes simplex virus (acute retinal necrosis) and cytomegalovirus retinitis impact immunocompromised individuals.
- Bacterial infections include syphilis, tuberculosis, and cat scratch disease (neuroretinitis). Parasitic infections like toxoplasmosis and toxocariasis cause chorioretinitis and choroidal granulomas, respectively.
Impact:
- Understanding these infections is crucial for timely diagnosis and management of vision-threatening ocular conditions.
- Recognizing the diverse etiologies aids in appropriate treatment strategies for patients with compromised immunity or systemic infections.
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