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Immunosuppressive therapy in bone marrow transplantation
1Department of Haematology, Royal Postgraduate Medical School, University of London, Hammersmith Hospital, U.K.
Immunosuppressive and immunomodulatory techniques have a central role in bone marrow transplantation (BMT). A wide range of agents with different mechanisms of action, including steroids, cyclosporin, cytotoxic agents, irradiation and monoclonal antibodies are used to achieve the following treatment aims: (1) Suppression of the recipient's immunity to permit donor marrow engraftment and prevent graft rejection; (2) Prevention of graft versus host disease (GvHD); (3) Treatment of established acute or chronic GvHD.
Immunosuppressive and immunomodulatory techniques have a central role in bone marrow transplantation (BMT). A wide range of agents with different mechanisms of action, including steroids, cyclosporin, cytotoxic agents, irradiation and monoclonal antibodies are used to achieve the following treatment aims: (1) Suppression of the recipient's immunity to permit donor marrow engraftment and prevent graft rejection; (2) Prevention of graft versus host disease (GvHD); (3) Treatment of established acute or chronic GvHD.