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Updated: Jun 26, 2026

Preparation and Observation of Thick Biological Samples by Scanning Transmission Electron Tomography
Published on: March 12, 2017
ENHANCEMENT OF CELL BOUNDARIES IN TRANSMISSION ELECTRON MICROSCOPY IMAGES
Tolga Tasdizen1, Ross Whitaker, Robert Marc
1Scientific Computing and Imaging Institute University of Utah Salt Lake City, UT.
Abstract:
Transmission electron microscopy (TEM) is an important modality for the analysis of cellular structures in neurobiology. The computational analysis of neurons entail their segmentation and reconstruction from TEM images. This problem is complicated by the heavily textured nature of cellular TEM images and typically low signal-to-noise ratios. In this paper, we propose a new partial differential equation for enhancing the contrast and continuity of cell membranes in TEM images.
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