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HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term results
Caio Scocco1, Sérgio Kwitko, Samuel Rymer
1Estagiário do Setor de Retina e Vítreo do Hospital de Olhos do Paraná - Curitiba (PR) - Brasil. cscocco@gmail.com
Purpose:
To evaluate the long-term outcome of HLA-matched lr-CLAL for bilateral ocular surface disorders.
Methods:
A retrospective, non-comparative interventional case series study of 39 eyes of 32 patients with bilateral surface disorders and clinical diagnosis of limbal stem cell deficiency who underwent HLA-matched lr-CLAL. Visual acuity (VA), ambulatory vision (> or = 20/200) and ocular surface stability were evaluated as main outcomes. Donor limbus was obtained from a sibling or a parent of the patient, after an appropriate Class I and II HLA match.
Results:
One year after surgery, VA improved in 46.2%, ambulatory vision was achieved in 48.7% and a stable corneal surface was achieved in 84.6% of the eyes. At the final follow-up (mean, 48.7 +/- 30.6 months), 66.6% of the eyes that had gained VA one year after surgery maintained an improved VA (p=0.28), 94.7% of eyes that had achieved ambulatory vision one year after surgery maintained 20/200 or better (p<0.001) and 93.9% still had a stable corneal surface (p=0.043) at the final follow-up.
Conclusions:
HLA-matched lr-CLAL can be an adequate method of treatment for bilateral ocular surface disorders, with a reasonable percentage of success of long-term results.
