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Robust computer-controlled system for intracytoplasmic sperm injection and subsequent cell electro-activation.

K K Tan¹, S Huang, K Z Tang

¹National University of Singapore, Engineering Drive 3, Singapore.

The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS

|January 27, 2009

Summary

A new computer-controlled system automates intracytoplasmic sperm injection (ICSI) and cell electro-activation, improving efficiency for male infertility treatments. This technology enhances precision and speed compared to manual methods.

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Area of Science:

Reproductive Medicine
Biomedical Engineering
Assisted Reproductive Technology

Background:

Male factor infertility is a significant concern addressed by assisted reproductive technologies.
Intracytoplasmic sperm injection (ICSI) and cell electro-activation are advanced procedures requiring skilled embryologists.
Current methods can be time-consuming, highlighting the need for automation.

Purpose of the Study:

To develop and present a computer-controlled system for ICSI and cell electro-activation.
To enhance the precision and efficiency of assisted reproductive procedures.
To reduce reliance on manual operation by experienced embryologists.

Main Methods:

Integration of a computer-controlled system with a microinjection workstation and piezo-actuator for ICSI.

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Published on: February 9, 2015

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Manipulation and In Vitro Maturation of Xenopus laevis Oocytes, Followed by Intracytoplasmic Sperm Injection, to Study Embryonic Development

Manipulation and In Vitro Maturation of Xenopus laevis Oocytes, Followed by Intracytoplasmic Sperm Injection, to Study Embryonic Development

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Implementation of vision capability for precise automated component positioning.

Utilization of a micro-pump for automated medium refreshment and a heater plate for temperature control during electro-activation.

Main Results:

The developed system demonstrated effectiveness in experimental trials using mice oocytes.
The automated system showed comparable or superior performance to the current manual ICSI method.
Successful integration of modular components within a hardware architecture was achieved.

Conclusions:

The developed computer-controlled system offers a promising advancement for ICSI and electro-activation.
Further refinement of instrumentation tools can enhance system robustness and overall performance.
Automation in assisted reproduction holds potential for improved efficiency and accessibility.