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Related Experiment Video

Updated: Jun 26, 2026

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

Microsubthalamotomy effect at day 3: screening for determinants.

David Maltête1, Nathalie Chastan, Stéphane Derrey

  • 1Department of Neurology, Rouen University Hospital, Rouen, France. david.maltete@chu-rouen.fr

Movement Disorders : Official Journal of the Movement Disorder Society
|January 27, 2009
PubMed
Summary
This summary is machine-generated.

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Effects of deep brain stimulation on non motor fluctuations in Parkinson's disease (assessed with the NMF severity scale).

Clinical parkinsonism & related disorders·2026

The number of microelectrode tracks used during surgery predicts the micro-lesion effect (mSTN) that improves Parkinson's disease motor symptoms. This suggests surgical trajectory influences the therapeutic outcome.

Area of Science:

  • Neurosurgery
  • Neurology
  • Movement Disorders

Background:

  • The micro-lesion effect (mSTN) post-implantation improves Parkinson's disease (PD) motor disability.
  • This effect is typically attributed to post-traumatic tissue reactions within the subthalamic nucleus (STN).
  • Predictors for the mSTN effect, including pre- and intraoperative factors, have not been previously identified.

Purpose of the Study:

  • To investigate whether pre- and intraoperative factors can predict the mSTN effect in Parkinson's disease patients undergoing STN stimulation.

Main Methods:

  • Assessed preoperative clinical characteristics (age, disease duration, cognitive scores, medication response, motor fluctuations, dyskinesia) in 40 PD patients.
  • Evaluated intraoperative parameters including the number of tracks and distances of neuronal activity recordings.

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Last Updated: Jun 26, 2026

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  • Utilized multiple stepwise regression analysis to identify predictors of the contralateral mSTN effect.

    • Main Results:

    • The number of tracks used for microelectrode recordings was the sole significant predictor of the contralateral mSTN effect (F(4,73) = 1.83, P = 0.02).
    • Other assessed clinical and intraoperative factors did not predict the mSTN effect.

    Conclusions:

    • The contralateral mSTN effect appears to be dependent on tissue alterations along the entire surgical trajectory.
    • These tissue changes may affect both the STN and adjacent brain structures, influencing the therapeutic outcome.