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Updated: Jun 26, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
High resolution computed tomography in idiopathic interstitial pneumonias
Pamela A Argiriadi1, David S Mendelson
1Mount Sinai School of Medicine, New York, NY, USA. pamela.argiriadi@mountsinai.org
The American Thoracic Society and European Respiratory Society established a classification for idiopathic interstitial pneumonias in 2001. This framework aids in diagnosing these lung diseases based on histology and imaging.
Area of Science:
- Pulmonology
- Pathology
- Radiology
Background:
- Idiopathic interstitial pneumonias (IIPs) are a group of lung diseases with unknown causes.
- These conditions involve inflammation and fibrosis in the lung parenchyma.
- Previous classification systems lacked standardization.
Purpose of the Study:
- To establish a standardized classification for idiopathic interstitial pneumonias.
- To define diagnostic criteria based on histological findings.
- To correlate histological patterns with imaging findings on high-resolution computed tomography (HRCT).
Main Methods:
- An international multidisciplinary consensus was convened.
- The consensus reviewed existing knowledge on IIPs.
- Diagnostic criteria were developed based on histopathology and HRCT imaging.
Main Results:
- A new classification system for IIPs was established in June 2001.
- The classification includes specific entities like usual interstitial pneumonia, nonspecific interstitial pneumonia, and others.
- Histological criteria were defined, correlating with HRCT patterns.
Conclusions:
- The consensus provided a standardized approach to diagnosing IIPs.
- This classification aids in differentiating various interstitial lung diseases.
- It emphasizes the importance of integrating histopathology and HRCT for accurate diagnosis.
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