Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Intestinal intraepithelial lymphocytes.

N Cerf-Bensussan¹, D Guy-Grand

¹Immunologie et Rhumatologie Pédiatriques, INSERM Unité 132, Hôpital des Enfants-Malades, Paris, France.

Gastroenterology Clinics of North America

|September 1, 1991

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical Heterogeneity of Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome: A French Multicenter Retrospective Study.

Clinical and translational gastroenterology·2018

Same author

IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria.

Mucosal immunology·2016

Same author

Enteropathy-associated T-cell lymphoma: improving treatment strategies.

Digestive diseases (Basel, Switzerland)·2015

Same author

Lessons from rodent models in celiac disease.

Mucosal immunology·2014

Same author

Olmesartan-associated enteropathy: results of a national survey.

Alimentary pharmacology & therapeutics·2014

Same author

Abnormal apical-to-basal transport of dietary ovalbumin by secretory IgA stimulates a mucosal Th1 response.

Mucosal immunology·2013

Same journal

Living Donor Intestinal and Liver Transplantation.

Gastroenterology clinics of North America·2026

Same journal

Living Abdominal Organ Donation: A Plan B That Saves Lives.

Gastroenterology clinics of North America·2026

Same journal

Long-Term Outcomes of Living Liver Donors.

Gastroenterology clinics of North America·2026

Same journal

Perioperative Management of Living Liver Donor Patients.

Gastroenterology clinics of North America·2026

Same journal

Living Donor Liver Transplantation for Colorectal Cancer Liver Metastasis.

Gastroenterology clinics of North America·2026

Same journal

Living Donor Liver Graft in Adult Populations: Donor Selection and Workup.

Gastroenterology clinics of North America·2026

See all related articles

Intestinal intraepithelial lymphocytes (IEL) are activated T cells in the gut. This review covers their phenotype, dual origin, and dual function in protecting or damaging the intestinal epithelium.

Area of Science:

Immunology
Gastroenterology
Cell Biology

Background:

Intestinal intraepithelial lymphocytes (IEL) are a significant population of T cells residing at the gut lining.
They are strategically positioned to interact with intestinal contents and epithelium.

Purpose of the Study:

To review current data on the phenotype, differentiation, and functions of IEL in both rodents and humans.
To elucidate the complex roles IEL play in intestinal health and disease.

Main Methods:

Review of recent scientific literature and experimental data.
Analysis of phenotypic studies (e.g., CD8, TCR alpha beta, TCR gamma delta expression).
Examination of experimental models investigating IEL origins and differentiation.

Related Experiment Videos

Main Results:

IEL are predominantly CD8-positive T cells with variable TCR alpha beta and TCR gamma delta expression.
Evidence suggests a dual origin for IEL, involving both thymus-dependent and thymus-independent pathways.
The gut epithelium plays a role in IEL differentiation.

Conclusions:

IEL possess a dual functional capacity: they can protect the intestinal epithelium.
Conversely, aberrant IEL activation can lead to epithelial damage.
Understanding IEL biology is crucial for managing intestinal inflammatory conditions.