Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Excellent Response to Oral Isotretinoin in a Pediatric Patient With Dissecting Cellulitis of the Scalp.

Cureus·2026
Same author

Interdigitating Dendritic Cell Sarcoma Arising on the Skin: An Exceedingly Rare Tumor With a Poor Prognosis.

The American Journal of dermatopathology·2026
Same author

A case of a rash after tetanus-diphtheria-pertussis and meningococcal vaccination.

Allergy and asthma proceedings·2024
Same author

CT imaging of condyloma acuminata.

Radiology case reports·2023
Same author

Epidermotropic Cutaneous Metastasis of Colonic Adenocarcinoma Presenting as a Sister Mary Joseph Nodule.

The American Journal of dermatopathology·2022
Same author

A rare case of aggressive cytotoxic T-cell lymphoma in a patient on dupilumab.

JAAD case reports·2022

Related Experiment Video

Updated: Jun 26, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Urticaria : a review.

Tasneem Poonawalla1, Brent Kelly

  • 1University of Texas Medical Branch, Galveston, Texas, USA.

American Journal of Clinical Dermatology
|January 28, 2009
PubMed
Summary
This summary is machine-generated.

Urticaria, a common skin condition, is often classified by duration and triggers. Chronic urticaria may involve autoantibodies, necessitating advanced treatments beyond standard antihistamines.

More Related Videos

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Related Experiment Videos

Last Updated: Jun 26, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Area of Science:

  • Immunology
  • Dermatology
  • Allergy

Background:

  • Urticaria is a common skin condition with varied classifications including acute, chronic, and physical types.
  • Urticarial vasculitis, contact urticaria, and special syndromes fall under the broad category of urticaria.
  • Understanding the pathogenesis of chronic urticaria has advanced, revealing autoantibodies in a significant patient subset.

Purpose of the Study:

  • To review the classification, pathogenesis, and management of urticaria.
  • To highlight recent findings in chronic urticaria, particularly the role of autoantibodies.
  • To discuss current and potential therapeutic strategies for urticaria.

Main Methods:

  • Literature review of urticaria classification and pathogenesis.
  • Analysis of recent advances in understanding chronic urticaria.
  • Overview of pharmacologic therapies for urticaria.

Main Results:

  • Chronic urticaria can be associated with autoantibodies to mast cell receptors in nearly half of patients with chronic idiopathic urticaria.
  • These patients may experience more severe disease and require more aggressive treatment approaches.
  • Extensive laboratory evaluations for chronic urticaria are often unrevealing, with no strong links to chronic infections or malignancy.

Conclusions:

  • Pharmacologic therapy for urticaria primarily involves histamine H(1) receptor antagonists.
  • Leukotriene receptor antagonists, corticosteroids, and immunomodulatory agents are options for severe, refractory cases.
  • Despite advances, chronic urticaria remains a challenging condition for many patients.