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NMDA receptor involvement in spatial delayed alternation in developing rats.

Deborah J Watson1, Mariel R Herbert, Mark E Stanton

  • 1Department of Psychology, University of Delaware, Newark, DE 19716, USA.

Behavioral Neuroscience
|January 28, 2009
PubMed
Summary
This summary is machine-generated.

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The NMDA receptor antagonist dizocilpine maleate (MK-801) impairs spatial working memory in developing rats. This disruption, particularly in the hippocampus, affects learning and memory development.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Pharmacology

Background:

  • NMDA receptors play a crucial role in synaptic plasticity and learning.
  • Spatial working memory is essential for navigation and cognitive function.
  • Developmental exposure to certain neurochemicals can impact long-term cognitive abilities.

Purpose of the Study:

  • To investigate the effects of dizocilpine maleate (MK-801) on spatial working memory during development in rats.
  • To determine if MK-801 administration during critical developmental periods impairs spatial learning and memory.
  • To explore the role of hippocampal plasticity in the ontogeny of spatial delayed alternation.

Main Methods:

  • Two experiments using Sprague-Dawley rats at different postnatal ages (P23, P26, P33).

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  • Administration of MK-801 (systemic or intrahippocampal) or saline.
  • Behavioral testing using a spatial delayed alternation (SDA) task in a T-maze.
  • Assessment of learning acquisition and performance.

    • Main Results:

    • Systemic MK-801 administration dose-dependently impaired spatial delayed alternation (SDA) learning in rats at both tested ages (P23 and P33).
    • Intrahippocampal MK-801 administration abolished the acquisition of SDA performance, suggesting a critical role for the hippocampus.
    • MK-801's specific impairment of SDA, without affecting position discrimination, points to a disruption of spatial working memory rather than general learning.

    Conclusions:

    • NMDA receptor antagonism with MK-801 disrupts the development of spatial working memory in rats.
    • Hippocampal plasticity is implicated in the ontogeny of spatial delayed alternation.
    • These findings highlight the vulnerability of developing neural circuits to NMDA receptor modulation.