Related Experiment Videos
[Tumor cell separation by cell saver and membrane filter passage]
M Wiesel1, C Güdemann, G Staehler
1Abteilung für Urologie, Univ. Heidelberg.
Infusionstherapie (Basel, Switzerland)
|June 1, 1991
Summary
Intraoperative autotransfusion may be safe for urological tumor surgery. Cell savers and filters removed all malignant cells from tested human tumor cell lines, suggesting potential for safe use in patients.
Area of Science:
- Urology
- Oncology
- Surgical Technology
Context:
- Intraoperative autotransfusion (IAT) is a technique to reinfuse a patient's own blood lost during surgery.
- Urological tumor surgeries carry a risk of malignant cell dissemination into the bloodstream.
- Cell salvage devices and leukocyte removal filters are used to process blood during surgery.
Purpose:
- To evaluate the efficacy of a cell saver and a leukocyte removal filter in removing malignant cells from blood.
- To determine the potential safety of using IAT in urological cancer surgery.
Summary:
- Human tumor cell lines (bladder, prostate, renal cell carcinoma) were suspended and processed through a cell saver and a leukocyte removal filter.
- Post-processing analysis revealed no detectable malignant cells in the solutions.
- This indicates a high potential for removing circulating tumor cells during processing.
Impact:
- These findings suggest that IAT could be a viable and safe option for patients undergoing urological tumor surgery.
- Further in vivo investigations are warranted to confirm the removal of malignant cells in actual patient blood.
- Successful implementation could reduce the risk of tumor recurrence due to iatrogenic metastasis during surgery.