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Updated: Jun 26, 2026

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
Published on: March 24, 2018
A modular synthesis of highly substituted imidazolium salts
Keiichi Hirano1, Slawomir Urban, Congyang Wang
1Organisch-Chemisches Institut der Westfalischen Wilhelms-Universitat Munster, Corrensstrasse 40, 48149 Munster, Germany.
Abstract:
A versatile and modular one-pot method for the preparation of differently substituted symmetrical and unsymmetrical imidazolium salts is reported, and 19 examples are given. In the key step, readily available formamidines and alpha-halo ketones are coupled to give imidazolinium salts 3, followed by imidazolium salt formation by acylation-induced elimination. For many substitution patterns of the imidazolium salt products, this efficient strategy compares favorably with well-known processes in terms of yield, ease of synthesis, and robustness.
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