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Red blood cell glutathione peroxidase activity in female nulligravid and pregnant rats
Giuseppe Gallo1, Guglielmo Martino
1Department of Cell Biology, University of Calabria, Rende, CS, Italy. pino72@tiscali.it
Background:
The alterations of the glutathione peroxidase enzyme complex system occur in physiological conditions such as aging and oxidative stress consequent to strenuous exercise.
Methods:
Authors optimize the spectrophotometric method to measure glutathione peroxidase activity in rat red blood cell membranes.
Results:
The optimization, when applied to age paired rats, both nulligravid and pregnant, shows that pregnancy induces, at seventeen d of pregnancy, an increase of both reactive oxygen substance concentration in red blood cells and membrane glutathione peroxidase activity.
Conclusion:
The glutathione peroxidase increase in erythrocyte membranes is induced by systemic oxidative stress long lasting rat pregnancy.
