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Hypocellular acute myeloid leukemia with bone marrow necrosis in young patients: two case reports
Deepali Jain1, Tejinder Singh, Naresh Kumar
1Department of Pathology, Maulana Azad Medical College, New Delhi, 110002, India. deepalijain76@gmail.com.
Introduction:
Hypocellular variants of acute myeloid leukemia are very rare and almost always occur in old aged patients. In contrast, hypocellular acute lymphoblastic leukemia usually occurs in children.
Case Presentation:
We report two Indian patients with hypocellular acute myeloid leukemia, a 32-year-old woman and a 13-year-old boy. Interestingly, one of the patients also showed bone marrow necrosis.
Conclusion:
Hypocellular acute myeloid leukemia is a rare entity and can affect young individuals. It can be considered as a rare cause of bone marrow necrosis.
Insights
Hypocellular acute myeloid leukemia is rare and can affect young patients, challenging typical age associations. This condition can also present as a rare cause of bone marrow necrosis.
Area of Science:
- Hematology
- Oncology
Background:
- Hypocellular acute myeloid leukemia (AML) is exceptionally rare, predominantly affecting elderly individuals.
- Conversely, hypocellular acute lymphoblastic leukemia (ALL) is typically observed in pediatric populations.
Purpose of the Study:
- To present two cases of hypocellular acute myeloid leukemia in young Indian patients.
- To highlight the association of hypocellular AML with bone marrow necrosis.
Main Methods:
- Case report of two patients diagnosed with hypocellular acute myeloid leukemia.
- Clinical and hematological data review, including bone marrow morphology and necrosis assessment.
Main Results:
- Two Indian patients, a 32-year-old woman and a 13-year-old boy, were diagnosed with hypocellular AML.
- One patient presented with concurrent bone marrow necrosis, a rare finding in AML.
Conclusions:
- Hypocellular acute myeloid leukemia can occur in younger individuals, expanding its known demographic profile.
- Hypocellular AML should be considered as a potential, albeit rare, cause of bone marrow necrosis.
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