Related Experiment Videos
IgG4 autoantibodies to DNA in systemic lupus erythematosus patients
S Nagpal1, M S Namboodiri, B S Rao
1Department of Biochemistry, Indian Institute of Science, Bangalore.
International Archives of Allergy and Applied Immunology
|January 1, 1991
Abstract:
The presence of DNA-specific IgG4 antibodies was demonstrated in the sera of patients with systemic lupus erythematosus (SLE) by a microtiter solid-phase radioimmunoassay. A patient with distal interphalangeal swelling and extensive ulcers in the oral cavity, seronegative for anti-DNA antibodies of the IgG isotype, was found to have anti-DNA autoantibodies exclusively of the IgG4 subclass. These autoantibodies directed against the dsDNA conformation cross-reacted with chondroitin sulfate, dermatan sulfate and heparin.