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Peripheral denervation suppresses the late phase of delayed-type hypersensitivity
E Josefsson1, H Carlsten, S Lange
1Department of Clinical Immunology, University of Göteborg, Sweden.
International Archives of Allergy and Applied Immunology
|January 1, 1991
Summary
Peripheral denervation significantly suppresses inflammatory immune responses, impacting both T cell-dependent and independent reactions. This effect was observed locally and even in contralateral limbs, suggesting a reflex arch mechanism.
Area of Science:
- Neuroimmunology
- Peripheral Nervous System Research
- Inflammation Studies
Background:
- Peripheral nerves play a role in regulating immune responses.
- Understanding the neuro-immune axis is crucial for inflammatory disease research.
Purpose of the Study:
- To investigate the impact of peripheral denervation on antigen-specific immune responses.
- To analyze the effects on both B cell and T cell mediated immunity.
Main Methods:
- Utilized a mouse model to study delayed-type hypersensitivity (DTH) response to sheep red blood cells (SRBC) and oxazolone.
- Assessed serum antibody levels via ELISA to evaluate B cell response.
- Investigated denervation effects at sensitization and elicitation points.
Main Results:
- Peripheral denervation significantly suppressed the local DTH response, particularly the late inflammatory phase.
- Denervation reduced inflammatory DTH reactivity even in the contralateral limb, suggesting a reflex arch involvement.
- Antibody response to SRBC was not affected by denervation.
- Footpad swelling induced by cholera toxin was also suppressed by denervation.
Conclusions:
- Peripheral denervation abrogates T cell-dependent and independent inflammatory responses.
- The findings suggest a role for neural reflexes in modulating local inflammation.