Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Two-Track Model of Huntington's Disease Pathology: Striatal Atrophy Mediates Maladaptive Immune Dysregulation.

International journal of molecular sciences·2026
Same author

Shape matters: Predicting Huntington's disease using progression modelling.

Computer methods and programs in biomedicine·2026
Same author

Mapping Regional Brain Aging in Huntington's Disease Using Structural Magnetic Resonance Imaging and Machine Learning.

Movement disorders : official journal of the Movement Disorder Society·2025
Same author

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease.

Annals of clinical and translational neurology·2025
Same author

Beyond Alzheimer's disease-translating biomarker insights across CNS diseases.

Science translational medicine·2025
Same author

Systematic Review with Meta-Analysis of Biofluid Markers for Huntington's Disease.

Movement disorders : official journal of the Movement Disorder Society·2025
Same journal

Opportunities and challenges for the application of single-cell RNA sequencing and spatial transcriptomics in ischemic stroke.

Experimental neurology·2026
Same journal

Behavioral and functional characterization of early-stage Parkinson's disease models reveals attentional deficits and circuit-level connectivity alterations.

Experimental neurology·2026
Same journal

Neuropathological and functional impact of astrocyte-derived extracellular vesicles in an aged model of Alzheimer's disease.

Experimental neurology·2026
Same journal

PI3K/Akt pathway in ischemic stroke: A central regulator of neuronal survival and repair.

Experimental neurology·2026
Same journal

Hepatokines and stellakines in liver and neurological diseases: The liver-brain axis.

Experimental neurology·2026
Same journal

Structural dynamics of α-Synuclein: Multi-scale imaging insights into pathological progression across Synucleinopathies.

Experimental neurology·2026
See all related articles

Related Experiment Video

Updated: Jun 26, 2026

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

Functional imaging in Huntington's disease.

Jane S Paulsen1

  • 1Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA. jane-paulsen@uiowa.edu

Experimental Neurology
|January 28, 2009
PubMed
Summary
This summary is machine-generated.

Functional neuroimaging detects early Huntington's disease (HD) changes before structural damage is evident. This review highlights PET and fMRI's role in understanding HD's complex progression.

More Related Videos

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
08:27

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

Related Experiment Videos

Last Updated: Jun 26, 2026

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
08:27

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

Area of Science:

  • Neuroscience
  • Genetics
  • Medical Imaging

Background:

  • Huntington's disease (HD) is a progressive genetic neurodegenerative disorder affecting motor control, cognition, and emotion.
  • Clinical symptoms and brain atrophy in HD manifest decades after initial pathological changes.
  • Functional neuroimaging offers potential for earlier detection of HD-related brain alterations compared to structural methods.

Purpose of the Study:

  • To review the application of functional neuroimaging techniques in Huntington's disease research.
  • To discuss the strengths and limitations of PET and fMRI in studying early HD.
  • To provide recommendations for future functional imaging studies in HD.

Main Methods:

  • Systematic review of published PET and fMRI studies involving Huntington's disease patients.
  • Analysis of imaging data focusing on neuronal dysfunction, tissue repair, and circuitry reorganization.
  • Evaluation of the sensitivity of functional imaging in detecting pre-symptomatic and early-stage HD.

Main Results:

  • Functional neuroimaging modalities like PET and fMRI show promise in identifying subtle, early changes in brain function preceding gross structural damage in HD.
  • These techniques can reveal complex alterations in neuronal activity and connectivity, offering insights beyond simple tissue loss.
  • The review synthesizes findings from various studies, underscoring the potential of functional imaging to track disease progression and therapeutic responses.

Conclusions:

  • Functional neuroimaging is a sensitive tool for detecting early pathogenic processes in Huntington's disease.
  • PET and fMRI can provide a more nuanced understanding of HD pathophysiology than structural imaging alone.
  • Further research employing advanced functional imaging techniques is recommended to improve early diagnosis and develop effective treatments for HD.